ABSTRACT
Introduction: Coagulopathy is commonly seen with coronavirus disease (COVID-19). Abnormal coagulation parameters are important to determine the prognosis and severity of the disease. There is scant evidence of coagulation in the Omicron variant of COVID-19. This study aimed to analyse the correlation between D-dimer level and clinical severity among 284 hospitalised patients with COVID in Jakarta, Indonesia. Methods: A retrospective cross-sectional study was conducted among 284 patients with COVID-19 admitted to Wisma Atlet Kemayoran COVID-19 Emergency Hospital between August 2021 and January 2022. D-dimer levels were determined on I-Chroma cs2100 and x-rays were taken with a Rotanode E7239X. p<0.05 was defined as statistically significant. The analytics were calculated using SPSS ver. 21. Results: Elevated D-dimer was discovered in 175 patients with the Omicron variant of COVID-19 (61.61%). Radiological signs of pneumonia were found in 38 patients (13.3%). Only one patient (0.35% severity rate) was diagnosed with a severe clinical case. A correlation was identified between an elevated D-dimer level and radiological signs of pneumonia in the Omicron variant of COVID-19 (p=0.045). Conclusion: The Omicron variant of COVID-19 tends to generate milder symptoms and less severe cases. Elevated D-dimer can be one of the signs of severity in the Omicron variant of COVID-19 due to its correlation with radiological signs of pneumonia. © 2022 UPM Press. All rights reserved.
ABSTRACT
BACKGROUND: Pneumomediastinum is a rare disease associated with barotrauma and uncommonly occurs in viral pneumonia. Although the underlying mechanism of the incidence of pneumomediastinum in COVID-19 patients is not fully understood, barotrauma is the most probable cause. CASE REPORT: We reported a case of a 27-year-old woman with the chief complaint that was shortness of breath and diagnosed with COVID-19 based on reverse transcription polymerase chain reaction examination. On the 6th day after being admitted to the hospital, suddenly, the intensity of dyspnea was increased with the decrease of oxygen saturation. Computerized tomography of the chest confirmed pneumomediastinum and pneumonia COVID-19. There was no improvement of symptoms after oxygen and steroid administration. Emergency thoracotomy was not performed;yet, and the patient has died. CONCLUSIONS: Although pneumomediastinum is benign disease and self-limited disease, the presents of pneumomediastinum may relate to worse outcomes in COVID-19 infections.